Since the first half of the twentieth century, evolutionary theory has been dominated by the
idea that mutations occur randomly with respect to their consequences. Here we test this …

DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular
homeostasis and genome stability to result in tumorigenesis for inappropriate repair …

The environmental risk from long-term plastic pollution is growing. We investigated the multi
and trans-generational reproductive toxicity of nanoplastics (NPs) in Caenorhabditis …

The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …

DNA damage causes cancer, impairs development and accelerates aging. Transcription-
blocking lesions and transcription-coupled repair defects lead to developmental failure and …

Ionic liquids (ILs) become emerging pollutants and their toxicities earn increasing attentions.
Yet, their effects were seldom explored on reproduction which connects generations and …

Abstract The Repressor Element 1-silencing transcription factor (REST) represses a number
of neuronal genes in non-neuronal cells or in undifferentiated neural progenitors. Here, we …

Atrazine (ATR), a widely used triazine herbicide, is an environmental endocrine disruptor
that can cause health problems. However, whether there are multi/trans-generational …

Some epigenetic information can be transmitted between generations without changes in
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …