Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …

Proliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly
proliferative cells and thereby develop a broad‐spectrum cancer therapeutic. It interacts with …

Proliferating cell nuclear antigen (PCNA) is a cellular hub in DNA metabolism and a
potential drug target. Its binding partners carry a short linear motif (SLiM) known as the …

Proliferating cell nuclear antigen (PCNA) is the key regulator of human DNA metabolism.
One important interaction partner is p15, involved in DNA replication and repair. Targeting …

In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a
promising drug target for inhibition of DNA replication and translesion synthesis. The β …

The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication.
During this process, cells must ensure an accurate and complete genome replication when …

PARylation plays critical role in regulating multiple cellular processes such as DNA damage
response and repair, transcription, RNA processing, and stress response. More than 300 …

Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing
a wide variety of DNA-distorting lesions from the genome. The highly choreographed …

Objectives The aim of this study was to investigate the effect of Toll like receptor 4 (TLR4) on
fracture healing. Methods The open tibial fracture models in TLR4 knockout (TLR4−/−) and …