Exercise induces signaling networks to improve muscle function and confer health benefits.
To identify divergent and common signaling networks during and after different exercise …

Small-molecule inhibitors of enzymes are widely used tools in reverse chemical genetics to
probe biology and explore therapeutic opportunities. They are often compared with genetic …

Increasing cell size drives changes to the proteome, which affects cell physiology. As cell
size increases, some proteins become more concentrated while others are diluted. As a …

Werner syndrome (WS) is a hereditary premature aging disorder characterized by visceral
fat accumulation and subcutaneous lipoatrophy, resulting in severe insulin resistance …

New protein synthesis is regulated both at the level of mRNA transcription and translation.
RNA-Seq is effective at measuring levels of mRNA expression, but techniques to monitor …

Inhibition of mammalian target of rapamycin (mTOR), which is a component of both
mTORC1 and mTORC2, leads to clinical benefits for organ transplant recipients. Pathways …

Endogenous positively charged organic substances, including neurotransmitters and
cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic …

Aging is inevitable, but the lifespan (duration of life) and healthspan (healthy aging) vary
greatly among individuals and across species. Unlocking the secrets behind these …

Subconjunctival fibrosis is the major cause of failure in both conventional and modern
minimally invasive glaucoma surgeries (MIGSs) with subconjunctival filtration. The search …

Protein synthesis (mRNA translation) plays a crucial role in cell function by shaping the
proteome–making all the proteins each cell requires at the right time and in the right …