Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

New Findings What is the topic of this review? This review provides a comprehensive
overview of Nox5 from basic biology to human disease and highlights unique features of this …

Historically, ROS have been considered toxic molecules, especially when their intracellular
concentration reaches high values. However, physiological levels of ROS support crucial …

Reactive oxygen species (ROS), which were originally classified as exclusively deleterious
compounds, have gained increasing interest in the recent years given their action as bona …

Oxygen is the sustenance of aerobic life and yet is highly toxic. In early life, antioxidants
functioned solely to defend against toxic effects of reactive oxygen species (ROS). Later, as …

Infection by rapidly growing Mycobacterium abscessus is increasingly prevalent in cystic
fibrosis (CF), a genetic disease caused by a defective CF transmembrane conductance …

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of
cells throughout the body. While multiple proteins have been characterized as affecting actin …

The generation of abnormally high levels of reactive oxygen species (ROS) is linked to
cellular dysfunction, including neuronal toxicity and neurodegeneration. However …

Reactive oxygen species (ROS) are critical for maintaining cellular homeostasis and
function when produced in physiological ranges. Important sources of cellular ROS include …