Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Perinatal arterial ischemic stroke is a relatively common and serious neurologic disorder that
can affect the fetus, the preterm, and the term-born infant. It carries significant long-term …

Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI)
encephalopathy. However, the efficacy of HT in preclinical models, such as the Vannucci …

Objectives To examine whether using an amplitude-integrated electroencephalography
(aEEG) severity pattern as an entry criterion for therapeutic hypothermia better selects …

Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability
associated with sustained oxidative stress, neuroinflammation, and cell death, affecting …

It is widely suggested in neonatal rodent studies that sex critically modulates the impact of
many neuroprotective interventions, such as therapeutic hypothermia. 1 Individual studies …

Abstract Background The Vannucci procedure is widely used to model cerebral hypoxic-
ischemic (HI) injury in neonatal rodents. Identifying minimally invasive biomarkers linked to …

Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to
the neonatal brain during labor, leading to infant mortality or severe brain damage, with a …

Excitotoxicity is a primary pathological process that occurs during stroke, traumatic brain
injury (TBI), and global brain ischemia such as perinatal asphyxia. Excitotoxicity is triggered …

Background: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven
treatment option. Although established as a neuroprotective therapy, benefit from HT has …