Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

The basal ganglia are subcortical brain structures involved in motor control, cognition, and
emotion regulation. We conducted univariate and multivariate genome-wide association …

Alzheimer's disease (AD) consists of two main pathologies, which are the deposition of
amyloid plaque as well as tau protein aggregation. Evidence suggests that not everyone …

Despite advances, the roles of genetic variants from the APOE-harboring 19q13. 32 region
in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach …

Alzheimer's disease (AD) is an incurable neurodegenerative disease, so it is important to
intervene in the early stage of the disease. Brain imaging genetics is an effective technique …

Four decades ago in 1985, alleles of apolipoprotein E (ApoE) ε2/ε3/ε4 became famous for
explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark …

Most heritable diseases are polygenic. To comprehend the underlying genetic architecture,
it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic …

Background Genetic variants within the APOE locus may modulate Alzheimer's disease (AD)
risk independently or in conjunction with APOE* 2/3/4 genotypes. Identifying such variants …

Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be
associated with complex haplotypes or compound genotypes. Methods We examined …

Optical neuritis (ON), otherwise known as optical nerve damage, is a term used to describe
various environmental and body conditions that lead to optic nerve dysfunction. Neurologists …