Mitochondrial heterogeneity in diseases

L Chen, M Zhou, H Li, D Liu, P Liao, Y Zong… - … and Targeted Therapy, 2023 - nature.com
As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

The role of short-chain fatty acids in inflammatory skin diseases

X Xiao, X Hu, J Yao, W Cao, Z Zou, L Wang… - Frontiers in …, 2023 - frontiersin.org
Short-chain fatty acids (SCFAs) are metabolites of gut microbes that can modulate the host
inflammatory response, and contribute to health and homeostasis. Since the introduction of …

The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence

A Hanaford, SC Johnson - Orphanet Journal of Rare Diseases, 2022 - Springer
Background Genetic mitochondrial diseases represent a significant challenge to human
health. These diseases are extraordinarily heterogeneous in clinical presentation and …

S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome

F Chen, C Ni, X Wang, R Cheng, C Pan… - EMBO Molecular …, 2022 - embopress.org
In this report, we discovered a new entity named cataract, alopecia, oral mucosal disorder,
and psoriasis‐like (CAOP) syndrome in two unrelated and ethnically diverse patients …

Gut–microbiota–brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence

X Wan, A Eguchi, Y Qu, Y Yang, L Chang… - European Archives of …, 2022 - Springer
Increasing epidemiological evidence shows that the use of cannabis during adolescence
could increase the risk for psychosis in adulthood. However, the precise mechanisms …

C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita

CF Guerrero-Juarez, P Schilf, J Li, MP Zappia… - Frontiers in …, 2023 - frontiersin.org
Introduction Inflammatory epidermolysis bullosa acquisita (EBA) is characterized by a
neutrophilic response to anti-type VII collagen (COL7) antibodies resulting in the …

Current knowledge in skin metabolomics: updates from literature review

A Paganelli, V Righi, E Tarentini… - International Journal of …, 2022 - mdpi.com
Metabolomic profiling is an emerging field consisting of the measurement of metabolites in a
biological system. Since metabolites can vary in relation to different stimuli, specific …

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

TC Wikramanayake, J Chéret, A Sevilla… - Expert opinion on …, 2022 - Taylor & Francis
Introduction The analysis of the role of the mitochondria in oxidative damage and skin aging
has been a significant aspect of dermatological research. Mitochondria generate most …

Independent and sensory human mitochondrial functions reflecting symbiotic evolution

GB Stefano, P Büttiker, S Weissenberger… - Frontiers in Cellular …, 2023 - frontiersin.org
The bacterial origin of mitochondria has been a widely accepted as an event that occurred
about 1.45 billion years ago and endowed cells with internal energy producing organelle …

Mitochondrial DNA heteroplasmy as an informational reservoir dynamically linked to metabolic and immunological processes associated with COVID-19 neurological …

GB Stefano, RM Kream - Cellular and Molecular Neurobiology, 2022 - Springer
Mitochondrial DNA (mtDNA) heteroplasmy is the dynamically determined co-expression of
wild type (WT) inherited polymorphisms and collective time-dependent somatic mutations …