Agglomeration: when folded proteins clump together

ML Romero-Romero, H Garcia-Seisdedos - Biophysical reviews, 2023 - Springer
Protein self-association is a widespread phenomenon that results in the formation of
multimeric protein structures with critical roles in cellular processes. Protein self-association …

Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells

H Garcia Seisdedos, T Levin… - Proceedings of the …, 2022 - National Acad Sciences
Understanding the molecular consequences of mutations in proteins is essential to map
genotypes to phenotypes and interpret the increasing wealth of genomic data. While …

How do particles with complex interactions self-assemble?

L Koehler, P Ronceray, M Lenz - Physical Review X, 2024 - APS
In living cells, proteins self-assemble into large functional structures based on specific
interactions between molecularly complex patches. Because of this complexity, protein self …

The near-symmetry of protein oligomers: NMR-derived structures

M Bonjack, D Avnir - Scientific Reports, 2020 - nature.com
The majority of oligomeric proteins form clusters which have rotational or dihedral symmetry.
Despite the many advantages of symmetric packing, protein oligomers are only nearly …

Oligomeric interactions maintain active‐site structure in a noncooperative enzyme family

Y Li, R Zhang, C Wang, F Forouhar, OB Clarke… - The EMBO …, 2022 - embopress.org
The evolutionary benefit accounting for widespread conservation of oligomeric structures in
proteins lacking evidence of intersubunit cooperativity remains unclear. Here, crystal and …

Application of computational docking to the characterization and modulation of protein-protein interactions of biomedical interest

M Rosell Oliveras - 2020 - diposit.ub.edu
[eng] The study of the 3D structural details of protein interactions is essential to understand
biomolecular functions at the molecular level. In this context, the limited availability of …