Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

SC Esteves, A Zini, RM Coward, DP Evenson… - Andrologia, 2021 - Wiley Online Library
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Oxidative stress and male infertility

T Takeshima, K Usui, K Mori, T Asai… - Reproductive …, 2021 - Wiley Online Library
Abstract Background Between 30% and 80% of patients with male infertility produce
excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male …

[HTML][HTML] Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

A Agarwal, A Majzoub, SC Esteves, E Ko… - Translational …, 2016 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

Intracytoplasmic sperm injection for male infertility and consequences for offspring

SC Esteves, M Roque, G Bedoschi, T Haahr… - Nature Reviews …, 2018 - nature.com
Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …

[HTML][HTML] Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development

R Gualtieri, G Kalthur, V Barbato, S Longobardi… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) generated at low levels during mitochondrial respiration
have key roles in several signaling pathways. Oxidative stress (OS) arises when the …

[PDF][PDF] Wang

Y Wang - Jia Z, Yi Q, Song L. The various components implied …, 2018 - tranassoc.com
Systems and methods are disclosed for communicating data in an integrated sensor network
having one or more nodes coupled to an optical sensor network and a radio frequency …

Role of genetics and epigenetics in male infertility

S Gunes, SC Esteves - Andrologia, 2021 - Wiley Online Library
Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …

[HTML][HTML] Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen …

SC Esteves, M Roque, CK Bradley, N Garrido - Fertility and sterility, 2017 - Elsevier
Objective To compare sperm DNA fragmentation (SDF) levels between testicular and
ejaculated sperm and to evaluate outcomes of intracytoplasmic sperm injection (ICSI) with …

Oxidative stress in the pathophysiology of male infertility

C Ritchie, EY Ko - Andrologia, 2021 - Wiley Online Library
The effects of reactive oxygen species on male fertility are governed by the oxidative
paradox, defined by a delicate balance between oxidative stress and antioxidant capacity …

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

SC Esteves, D Santi, M Simoni - Andrology, 2020 - Wiley Online Library
Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …