ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

S Cang, C Iragavarapu, J Savooji, Y Song… - Journal of hematology & …, 2015 - Springer
With the advent of new agents targeting CD20, Bruton's tyrosine kinase, and
phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist …

Targeting Bruton's tyrosine kinase with ibrutinib in B‐cell malignancies

Y Wang, LL Zhang, RE Champlin… - Clinical Pharmacology …, 2015 - Wiley Online Library
The B‐cell receptor signaling pathway, which is critical to the development and maturation of
normal B‐cells, is emerging as an attractive therapeutic target in B‐cell malignancies …

Venetoclax: Bcl-2 inhibition for the treatment of chronic lymphocytic leukemia.

G Del Poeta, M Postorino, L Pupo… - Drugs of Today …, 2016 - europepmc.org
Venetoclax (ABT-199) is a small-molecule selective oral inhibitor of the antiapoptotic protein
Bcl-2 that promotes programmed cell death of chronic lymphocytic leukemia (CLL) cells …

Retracted: Bevacizumab synergises with the BCL 2 inhibitor venetoclax to effectively treat B‐cell non‐Hodgkin's lymphoma

L Wang, S Peng, W Sun, X Liu - European journal of …, 2019 - Wiley Online Library
Objectives Our present study has shown a potential role for VEGF‐A‐mediated autocrine
signalling to promote survival and proliferation of SU‐DHL‐6 cells, but the cells could not …

Ibrutinib for mantle cell lymphoma

DL Tucker, SA Rule - Future Oncology, 2016 - Taylor & Francis
Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin lymphoma.
Ibrutinib is a first-in-class, oral inhibitor of Bruton's tyrosine kinase which acts by downstream …

Targeting Nuclear Export in Chronic Lymphocytic Leukemia

ZA Hing - 2018 - rave.ohiolink.edu
In the past decade there has been increased appreciation for the complexity and importance
of post-transcriptional processes that control gene regulation and post-translational …