DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

DNA methylation is a major epigenetic modification of the genome that regulates crucial
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …

We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts
by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and …

THE paternal and maternal genomes are not equivalent and both are required for
mammalian development1, 2. The difference between the parental genomes is believed to …

Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

It has been a controversial issue as to how many DNA cytosine methyltransferase
mammalian cells have and whether de novo methylation and maintenance methylation …

Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …

Differentially methylated sequences associated with imprinted genes are proposed to
control genomic imprinting. A 2-kb region located 5′ to the imprinted mouse H19 gene is …