Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Increasing evidence has shown that population dynamics are qualitatively different from
single-cell behaviors. Reporters to probe dynamic, single-cell behaviors are desirable yet …

Signals from commensal bacteria can influence immune cell development and susceptibility
to infectious or inflammatory diseases. However, the mechanisms by which commensal …

To obtain rates of mRNA synthesis and decay in yeast, we established dynamic
transcriptome analysis (DTA). DTA combines non‐perturbing metabolic RNA labeling with …

Cells coordinate intracellular activities in response to changes in the extracellular
environment to maximize their probability of survival and proliferation. Eukaryotic cells need …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

Recent computational studies indicate that the molecular noise of a cellular process may be
a rich source of information about process dynamics and parameters. However, accessing …

Signal transduction pathways control cellular responses to extrinsic and intrinsic signals.
The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation …

MAP kinase (MAPK) modules are conserved three-kinase cascades that serve central roles
in intracellular signal transduction in eukaryotic cells. MAPK pathways of different inputs and …