The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme …

We summarize the currently available information regarding the state of ionization and
tautomerization of the 4′‐aminopyrimidine ring of the thiamine diphosphate on enzymes …

The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing conversion of
pyruvate to acetyl-CoA comprises three components: E1p, E2p, and E3. The E2p is the five …

The idea of “reasonableness” of organic reactions is based on recorded evidence of
reaction patterns. The logical patterns are organized based on structural and functional …

The α-ketoglutarate dehydrogenase (KDH) complex is a major regulatory point of aerobic
energy metabolism. Mycobacterium tuberculosis was reported to lack KDH activity, and the …

Nature has evolved different strategies for the reversible cleavage of ketose phosphosugars
as essential metabolic reactions in all domains of life. Prominent examples are the Schiff …

Carbenes are highly reactive chemical compounds that are exploited as ligands in
organometallic chemistry and are powerful organic catalysts. They were postulated to occur …

The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-d-xylulose 5-phosphate
(DXP) synthase carries out the condensation of pyruvate as a 2-hydroxyethyl donor with d …

Emerging resistance of human pathogens to anti-infective agents make it necessary to
develop new agents to treat infection. The methylerythritol phosphate pathway has been …

It is recognized widely that enzymes promote reactions by providing a pathway that
proceeds through a transition state of lower energy. In principle, further rate enhancements …