Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury
Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical
impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key …
impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key …
[HTML][HTML] Neuroimmune and neuroinflammation response for traumatic brain injury
J Wu, R Ren, T Chen, LD Su, T Tang - Brain Research Bulletin, 2024 - Elsevier
Traumatic brain injury (TBI) is one of the major diseases leading to mortality and disability,
causing a serious disease burden on individuals' ordinary lives as well as socioeconomics …
causing a serious disease burden on individuals' ordinary lives as well as socioeconomics …
ATF4 knockdown in macrophage impairs glycolysis and mediates immune tolerance by targeting HK2 and HIF-1α ubiquitination in sepsis
T Liu, Z Wen, L Shao, Y Cui, X Tang, H Miao, J Shi… - Clinical …, 2023 - Elsevier
Strengthened glycolysis is crucial for the macrophage pro-inflammatory response during
sepsis. Activating transcription factor 4 (ATF4) plays an important role in regulating glucose …
sepsis. Activating transcription factor 4 (ATF4) plays an important role in regulating glucose …
Mailuo Shutong pills inhibit neuroinflammation by regulating glucose metabolism disorders to protect mice from cerebral ischemia-reperfusion injury
Y Guan, L Pan, D Niu, X Li, S Li, G Cheng… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Mailuo Shutong Pill (MLST), a traditional Chinese
medicine (TCM), has been widely used for clearing heat and detoxifying, eliminating stasis …
medicine (TCM), has been widely used for clearing heat and detoxifying, eliminating stasis …
Identification of new co-diagnostic genes for sepsis and metabolic syndrome using single-cell data analysis and machine learning algorithms
L Tao, Y Zhu, J Liu - Frontiers in Genetics, 2023 - frontiersin.org
Sepsis, a serious inflammatory response that can be fatal, has a poorly understood
pathophysiology. The Metabolic syndrome (MetS), however, is associated with many …
pathophysiology. The Metabolic syndrome (MetS), however, is associated with many …
A polycomb group protein EED epigenetically regulates responses in lipopolysaccharide tolerized macrophages
A Boonmee, S Benjaskulluecha, P Kueanjinda… - Epigenetics & …, 2024 - Springer
Background To avoid exaggerated inflammation, innate immune cells adapt to become hypo-
responsive or “tolerance” in response to successive exposure to stimuli, which is a part of …
responsive or “tolerance” in response to successive exposure to stimuli, which is a part of …
Emerging roles of lactate in acute and chronic inflammation
Y Fang, Z Li, L Yang, W Li, Y Wang, Z Kong… - Cell Communication and …, 2024 - Springer
Traditionally, lactate has been considered a 'waste product'of cellular metabolism. Recent
findings have shown that lactate is a substance that plays an indispensable role in various …
findings have shown that lactate is a substance that plays an indispensable role in various …
Potentiation of the axis involving pentose phosphate pathway/NADPH oxidase/reactive oxygen species drives higher IL‐10 production in monocytes of Sub‐Saharan …
MEB Ongwe, YD Mouwenda… - European Journal of …, 2024 - Wiley Online Library
Cellular metabolism is a key determinant of immune cell function. Here we found that CD14+
monocytes from Sub‐Saharan Africans produce higher levels of IL‐10 following TLR‐4 …
monocytes from Sub‐Saharan Africans produce higher levels of IL‐10 following TLR‐4 …
[HTML][HTML] Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time
The clinical presentation of COVID-19 is highly variable, and understanding the underlying
biological processes is crucial. This study utilized a proteomic analysis to investigate …
biological processes is crucial. This study utilized a proteomic analysis to investigate …
Deciphering the molecular classification of pediatric sepsis: integrating WGCNA and machine learning-based classification with immune signatures for the …
J Huang, J Chen, C Wang, L Lai, H Mi, S Chen - Frontiers in Genetics, 2024 - frontiersin.org
Introduction: Pediatric sepsis (PS) is a life-threatening infection associated with high
mortality rates, necessitating a deeper understanding of its underlying pathological …
mortality rates, necessitating a deeper understanding of its underlying pathological …