[HTML][HTML] SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …
particular risk for severe disease and death in older adults and in adults with age-related …
[HTML][HTML] Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
[HTML][HTML] Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
The twilight of immunity: emerging concepts in aging of the immune system
J Nikolich-Žugich - Nature immunology, 2018 - nature.com
Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
NA Duggal, G Niemiro, SDR Harridge… - Nature Reviews …, 2019 - nature.com
Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …
contributor to poor health in older adults, with increasing risk of infections, cancer and …
[HTML][HTML] I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people
AJ Pietrobon, FME Teixeira, MN Sato - Frontiers in immunology, 2020 - frontiersin.org
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …
that occur during the aging process. These changes named collectively as …
[HTML][HTML] Age-related immune alterations and cerebrovascular inflammation
CE Finger, I Moreno-Gonzalez, A Gutierrez… - Molecular …, 2022 - nature.com
Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …
development of many age-related diseases, including vascular disease. The world's …
Aging and lung disease
SJ Cho, HW Stout-Delgado - Annual review of physiology, 2020 - annualreviews.org
People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …
world's population over 60 years of age will nearly double. Natural lung aging is associated …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …
Ageing of the gut microbiome: potential influences on immune senescence and inflammageing
J Conway, NA Duggal - Ageing research reviews, 2021 - Elsevier
Advancing age is accompanied by changes in the gut microbiota characterised by a loss of
beneficial commensal microbes that is driven by intrinsic and extrinsic factors such as diet …
beneficial commensal microbes that is driven by intrinsic and extrinsic factors such as diet …