The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Modified nucleotides in tRNA are critical components of the translation apparatus, but their
importance in the process of translational regulation had until recently been greatly …

MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Synthetic messenger RNA (mRNA) tools often use pseudouridine and 5-methyl cytidine as
substitutions for uridine and cytidine to avoid the immune response and cytotoxicity induced …

The SpoU-TrmD (SPOUT) methyltransferase superfamily was designated when structural
similarity was identified between the transfer RNA–modifying enzymes TrmH (SpoU) and …

With the exponential growth in the determination of protein sequences and structures via
genome sequencing and structural genomics efforts, there is a growing need for reliable …

Pseudouridine is one of the well-known chemical modifications in various RNA species.
Current advances to detect pseudouridine show that the pseudouridine landscape is …

Successful pathogens must be able to adapt to a multitude of stressors imposed by their
host. Acinetobacter baumannii has emerged as a major global health threat due to its …

To improve and complete our knowledge of archaeal tRNA modification patterns, we have
identified and compared the modification pattern (type and location) in tRNAs of three very …