Gastric cancer remains a major unmet clinical problem with over 1 million new cases
worldwide. It is the fourth most commonly occurring cancer in men and the seventh most …

The tumor microenvironment (TME) harbors heterogeneous contents and plays critical roles
in tumorigenesis, metastasis, and drug resistance. Therefore, the deconvolution of the TME …

Recent decades have seen an alarming increase in the incidence of cardia gastric
adenocarcinoma (CGA) while noncardia gastric adenocarcinoma (NCGA) has decreased. In …

Gastric cancer (GC) represents a leading cause of cancer related morbidity and mortality
worldwide accounting for more than 1 million of newly diagnosed cases and thousands of …

Gastric cancer (GC) remains the fifth most prevalent cancer worldwide and the third leading
cause of global cancer mortality. Comprehensive‐omic studies have unveiled a …

BACKGROUND Specific features of the tumor microenvironment (TME) may provide useful
prognostic information. We conducted a systematic investigation of the cellular composition …

Substantial progress has been made in using deep learning for cancer detection and
diagnosis in medical images. Yet, there is limited success on prediction of treatment …

Background The tumour stroma microenvironment plays an important part in disease
progression and its composition can influence treatment response and outcomes …

The mesenchymal cancer phenotype is known to be clinically related to treatment resistance
and a poor prognosis. We identified gene signature-based molecular subtypes of gastric …

PURPOSE This phase Ib study evaluated the safety and efficacy of paclitaxel plus
navicixizumab, a bispecific antiangiogenic antibody to vascular endothelial growth factor …