Regeneration or repair? The role of alveolar epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF)

P Confalonieri, MC Volpe, J Jacob, S Maiocchi… - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial …

The occupational burden of nonmalignant respiratory diseases. An official American Thoracic Society and European Respiratory Society statement

PD Blanc, I Annesi-Maesano, JR Balmes… - American journal of …, 2019 - atsjournals.org
Rationale: Workplace inhalational hazards remain common worldwide, even though they
are ameliorable. Previous American Thoracic Society documents have assessed the …

Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities

P Spagnolo, CJ Ryerson, R Putman… - The Lancet …, 2021 - thelancet.com
Many patients with interstitial lung disease (ILD) develop pulmonary fibrosis, which can lead
to reduced quality of life and early mortality. Patients with fibrotic ILD often have …

Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses

Y Park, C Ahn, TH Kim - Scientific Reports, 2021 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease of unknown cause. It has a high risk of rapid progression and mortality. We …

TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis

Z Ye, Y Hu - International journal of molecular …, 2021 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge

WI Effendi, T Nagano - International Journal of Molecular Sciences, 2022 - mdpi.com
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …

Idiopathic pulmonary fibrosis: Molecular mechanisms and potential treatment approaches

DS Glass, D Grossfeld, HA Renna, P Agarwala… - Respiratory …, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease with high mortality that
commonly occurs in middle-aged and older adults. IPF, characterized by a decline in lung …

Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment

H Barnes, L Troy, CT Lee, A Sperling, M Strek… - Allergy, 2022 - Wiley Online Library
Hypersensitivity pneumonitis is an immune‐mediated interstitial lung disease caused by an
aberrant response to an inhaled exposure, which results in mostly T cell–mediated …

Oxidative stress in pulmonary fibrosis

E Otoupalova, S Smith, G Cheng… - Comprehensive …, 2011 - Wiley Online Library
Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Occupational and environmental risk factors for idiopathic pulmonary fibrosis in Australia: case–control study

MJ Abramson, T Murambadoro, SM Alif, GP Benke… - Thorax, 2020 - thorax.bmj.com
Introduction Idiopathic pulmonary fibrosis (IPF) is a lung disease of unknown cause
characterised by progressive scarring, with limited effective treatment and a median survival …