[HTML][HTML] Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced Science, 2021 - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

[HTML][HTML] Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

S Juengpanich, S Li, T Yang, T Xie, J Chen… - Nature …, 2023 - nature.com
Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared
(NIR) tissue penetration depth and low accumulation efficiency within the target sites …

[HTML][HTML] Rethink of EGFR in cancer with its kinase independent function on board

R Thomas, Z Weihua - Frontiers in oncology, 2019 - frontiersin.org
The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

Exercise-induced myokines and their effect on prostate cancer

JS Kim, DA Galvão, RU Newton, E Gray… - Nature Reviews …, 2021 - nature.com
Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

AA Shafi, AE Yen, NL Weigel - Pharmacology & therapeutics, 2013 - Elsevier
Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

Epithelial-mesenchymal transition (EMT) and prostate cancer

V Odero-Marah, O Hawsawi, V Henderson… - Cell & molecular biology …, 2018 - Springer
Typically the normal epithelial cells are a single layer, held tightly by adherent proteins that
prevent the mobilization of the cells from the monolayer sheet. During prostate cancer …

Human prostate cancer risk factors

DG Bostwick, HB Burke, D Djakiew… - … Journal of the …, 2004 - Wiley Online Library
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

[HTML][HTML] Androgen receptor signaling in prostate cancer development and progression

PE Lonergan, DJ Tindall - Journal of carcinogenesis, 2011 - ncbi.nlm.nih.gov
The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

[HTML][HTML] Epithelial-mesenchymal transition in prostate cancer: an overview

M Montanari, S Rossetti, C Cavaliere, C D'Aniello… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Prostate cancer is a main urological disease associated with significant morbidity and
mortality. Radical prostatectomy and radiotherapy are potentially curative for localized …