The high selection pressure applied in rice breeding since its domestication thousands of
years ago has caused a narrowing in its genetic variability. Obtaining new rice cultivars …

Since the discovery that nucleases of the bacterial CRISPR (clustered regularly interspaced
palindromic repeat)‐associated (Cas) system can be used as easily programmable tools for …

The CRISPR/C as nuclease is becoming a major tool for targeted mutagenesis in
eukaryotes by inducing double‐strand breaks (DSB s) at pre‐selected genomic sites that are …

Cells employ potentially mutagenic DNA repair mechanisms to avoid the detrimental effects
of chromosome breaks on cell survival. While classical non‐homologous end‐joining …

In January 2014, an international meeting sponsored by the International Life Sciences
Institute/Health and Environmental Sciences Institute and the Canadian Food Inspection …

Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-
prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation …

Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have
revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) …

The genomic sequences segregating in experimental populations are often highly divergent
from the community reference and from one another. Such divergence is problematic under …

Small tandem duplications of DNA occur frequently in the human genome and are
implicated in the aetiology of certain human cancers. Recent studies have suggested that …