The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

We have cloned a member of the steroid hormone receptor superfamily of ligand-activated
transcription factors. The receptor homologue is activated by a diverse class of rodent …

Mammalian circadian rhythms are generated by a feedback loop in which BMAL1 and
CLOCK, players of the positive limb, activate transcription of the cryptochrome and period …

The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects
are modest and it has been considered to be a secondary regulator of the cell-autonomous …

Three novel members of the Xenopus nuclear hormone receptor superfamily have been
cloned. They are related to each other and similar to the group of receptors that includes …

Von Recklinghausen neurofibromatosis (NF1) is a common autosomal dominant disorder
characterized by abnormalities in multiple tissues derived from the neural crest. No reliable …

I. Introduction T HE biological importance of the thyroid gland has been recognized for
centuries (1). The realization in the late 19th century that cretinism and myxedema result …

The ROSAβgeo26 (ROSA26) mouse strain was produced by random retroviral gene
trapping in embryonic stem cells. Staining of ROSA26 tissues and fluorescence-activated …

The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue
development that result in metamorphosis. To advance our understanding of the genetic …