Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

Highlights•Chronic drug use alters the epigenetic state of neurons and other cell types within
brain reward regions.•Epigenetic adaptations are correlated with addiction, but their causal …

HDAC 4, 5, 7 and 9 constitute the class II a histone deacetylases (HDAC s) within the large
family of protein deacetylases. Class II a HDAC s have unique features that distinguish them …

Abstract The literature about Developmental Origins of Health and Disease (DOHaD)
studies is considerably growing. Maternal and paternal environment, during all the …

Substance use disorders (SUDs) are highly prevalent. SUDs involve vicious cycles of binges
followed by occasional periods of abstinence with recurrent relapses despite treatment and …

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation
and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist …

Powerful associations that link drugs of abuse with cues in the drug-paired environment
often serve as prepotent relapse triggers. Drug-associated contexts and cues activate …

In response to environmental cues, enzymes that influence the functions of proteins, through
reversible post-translational modifications supervise the coordination of cell behavior like …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function. While genetic factors are important in the etiology of …