RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
Cold-shock domains—abundance, structure, properties, and nucleic-acid binding
U Heinemann, Y Roske - Cancers, 2021 - mdpi.com
Simple Summary Proteins are composed of compact domains, often of known three-
dimensional structure, and natively unstructured polypeptide regions. The abundant cold …
dimensional structure, and natively unstructured polypeptide regions. The abundant cold …
[HTML][HTML] Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
The RNA binding protein Lin28 is best known for the critical role in cell development, recent
researches also have implied its oncogenic function in various human cancers, including …
researches also have implied its oncogenic function in various human cancers, including …
A transcriptome-wide translational program defined by LIN28B expression level
FE Tan, S Sathe, EC Wheeler, JK Nussbacher, S Peter… - Molecular cell, 2019 - cell.com
LIN28 RNA binding proteins are dynamically expressed throughout mammalian
development and during disease. However, it remains unclear how changes in LIN28 …
development and during disease. However, it remains unclear how changes in LIN28 …
[HTML][HTML] Human lncRNAs harbor conserved modules embedded in different sequence contexts
We analyzed the structure of human long non-coding RNA (lncRNAs) genes to investigate
whether the non-coding transcriptome is organized in modular domains, as is the case for …
whether the non-coding transcriptome is organized in modular domains, as is the case for …
Structural insights of the pre-let-7 interaction with LIN28B
SI Rangel-Guerrero, PA Franco-Urquijo… - … Nucleotides & Nucleic …, 2020 - Taylor & Francis
Abstract The Let-7: LIN28 regulatory loop is a paradigm in miRNA regulation. LIN28 harbors
two RNA binding domains, which interact with well-conserved sequences in pre-let-7 RNAs …
two RNA binding domains, which interact with well-conserved sequences in pre-let-7 RNAs …
Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design
S De Franco, J Vandenameele, A Brans, O Verlaine… - Scientific reports, 2019 - nature.com
Transcriptomes consist of several classes of RNA that have wide-ranging but often poorly
described functions and the deregulation of which leads to numerous diseases. Engineering …
described functions and the deregulation of which leads to numerous diseases. Engineering …
Beyond an oncogene, Lin28 is a master regulator of cancer progression.
X Wang, M Weng, Y Jin, W Yang, D Wu… - Histology and …, 2017 - europepmc.org
The RNA binding protein Lin28 is increased in most human malignancies, and elevated
Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 …
Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 …
[PDF][PDF] Cold-Shock Domains—Abundance, Structure, Properties, and Nucleic-Acid Binding. Cancers 2021, 13, 190
U Heinemann, Y Roske - 2021 - pdfs.semanticscholar.org
The cold-shock domain has a deceptively simple architecture but supports a complex
biology. It is conserved from bacteria to man and has representatives in all kingdoms of life …
biology. It is conserved from bacteria to man and has representatives in all kingdoms of life …
Engineering RNA-Binding Proteins by Modular Assembly of RanBP2-Type Zinc Fingers
S De Franco, MR O'Connell, M Vandevenne - Zinc Finger Proteins …, 2018 - Springer
Deciphering the function of the nonprotein-coding portion of genomes represents one of the
major challenges that molecular biology is facing today. Numerous classes of RNAs have …
major challenges that molecular biology is facing today. Numerous classes of RNAs have …