Animal cell-based expression platforms enable the production of complex biomolecules
such as recombinant proteins and viral vectors. Although most biotherapeutics are produced …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

With the in-depth development of the market economy and the acceleration of the process of
urbanization, a large number of people have poured into the city, and a large number of …

The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …

Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …

Lentiviral vectors (LV) have seen considerably increase in use as gene therapy vectors for
the treatment of acquired and inherited diseases. This review presents the state of the art of …

Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene
delivery. Despite the resources poured into the development of ever more effective …

Highlights•Non-human mammalian cells can produce immunogenic glycans.•Several
human cells are now available for production of biopharmaceuticals.•Functional …

Background The demand of monospecific high affinity binding reagents, particularly
monoclonal antibodies, has been steadily increasing over the last years. Enhanced …

The demand for production of glycoproteins from mammalian cell culture continues with an
increased number of approvals as biopharmaceuticals for the treatment of unmet medical …