[HTML][HTML] Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction

Y Rivera-Cuevas, B Clough, EM Frickel - Current Opinion in Immunology, 2023 - Elsevier
Cell-intrinsic defense is an essential part of the immune response against intracellular
pathogens regulated by cytokine-induced proteins and pathways. One of the most …

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1

J Zhu, X Gao, Y Li, Z Zhang, S Xie… - Proceedings of the …, 2023 - National Acad Sciences
Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety
since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the …

The role of polymers in enabling RNAi-based technology for sustainable pest management

AI Quilez-Molina, J Niño Sanchez, D Merino - Nature Communications, 2024 - nature.com
The growing global food demand, coupled with the limitations of traditional pest control
methods, has driven the search for innovative and sustainable solutions in agricultural pest …

Guanylate-binding protein 2 exerts GTPase-dependent anti-ectromelia virus effect

Z Gao, Z Meng, X He, G Chen, Y Fang, H Tian… - Microorganisms, 2023 - mdpi.com
Guanylate-binding proteins (GBPs) are highly expressed interferon-stimulated genes (ISGs)
that play significant roles in protecting against invading pathogens. Although their functions …

P-Hydroxylcinnamaldehyde induces tumor-associated macrophage polarization toward the M1 type by regulating the proteome and inhibits ESCC in vivo and in vitro

X Wang, S Wei, W Li, X Wei, C Zhang, S Dai… - International …, 2023 - Elsevier
P-Hydroxylcinnamaldehyde (CMSP) was firstly isolated from Chinese medicine
Cochinchinnamomordica seed (CMS) by our team and has been verified to have growth …

Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments

X Zhang, Q Du, G Chen, Y Jiang, K Huang, L Li… - Veterinary …, 2023 - Springer
The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies,
responsible for severe economic losses to the swine industry worldwide. The interferon …

Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and …

L Schelle, JV Côrte-Real, S Fayyaz… - Frontiers in …, 2024 - frontiersin.org
Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are
widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases …

[HTML][HTML] Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of …

FV Marinho, C Brito, ACVSC de Araujo… - Frontiers in …, 2024 - frontiersin.org
Introduction Guanylate-binding proteins (GBPs) are produced in response to pro-
inflammatory signals, mainly interferons. The most studied cluster of GBPs in mice is on …

Evolution of guanylate binding protein genes shows a remarkable variability within bats (Chiroptera)

A Pinheiro, JR Borges, JV Côrte-Real… - Frontiers in …, 2024 - frontiersin.org
Background GBP s (guanylate binding proteins), an evolutionary ancient protein family, play
a key role in the host's innate immune response against bacterial, parasitic and viral …

The Viral Protein Poly (A) Polymerase Catalytic Subunit Interacts with Guanylate-Binding Proteins 2 to Antagonize the Antiviral Ability of Targeting Ectromelia Virus

Z Gao, X He, G Chen, Y Fang, Z Meng, H Tian… - International Journal of …, 2023 - mdpi.com
The recent spread of the monkeypox virus among humans has heightened concerns
regarding orthopoxvirus infections. Consequently, conducting a comprehensive study on the …