Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

DR Nässel, M Zandawala - Progress in neurobiology, 2019 - Elsevier
This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

DR Nässel, M Zandawala - Open Biology, 2022 - royalsocietypublishing.org
Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

Hunger-driven motivational state competition

CJ Burnett, C Li, E Webber, E Tsaousidou, SY Xue… - Neuron, 2016 - cell.com
Behavioral choice is ubiquitous in the animal kingdom and is central to goal-oriented
behavior. Hypothalamic Agouti-related peptide (AgRP) neurons are critical regulators of …

Potent anticancer activity of a novel iridium metallodrug via oncosis

E Ortega-Forte, S Hernández-García… - Cellular and Molecular …, 2022 - Springer
Oncosis (from Greek ónkos, meaning “swelling”) is a non-apoptotic cell death process
related to energy depletion. In contrast to apoptosis, which is the main form of cell death …

Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

D Wilinski, J Winzeler, W Duren, JL Persons… - Nature …, 2019 - nature.com
Metabolites are active controllers of cellular physiology, but their role in complex behaviors
is less clear. Here we report metabolic changes that occur during the transition between …

Modification of feeding circuits in the evolution of social behavior

EK Fischer, LA O'Connell - Journal of Experimental Biology, 2017 - journals.biologists.com
Adaptive trade-offs between foraging and social behavior intuitively explain many aspects of
individual decision-making. Given the intimate connection between social behavior and …

The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish

M Zaupa, N Nagaraj, A Sylenko, H Baier… - Neuron, 2024 - cell.com
Animals constantly need to judge the valence of an object in their environment: is it potential
food or a threat? The brain makes fundamental decisions on the appropriate behavioral …

Expansion and Accelerated Evolution of 9-Exon Odorant Receptors in Polistes Paper Wasps

AW Legan, CM Jernigan, SE Miller… - Molecular Biology …, 2021 - academic.oup.com
Independent origins of sociality in bees and ants are associated with independent
expansions of particular odorant receptor (OR) gene subfamilies. In ants, one clade within …

Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons

M Wagle, M Zarei, M Lovett-Barron, KT Poston… - Molecular …, 2022 - nature.com
Salient sensory stimuli are perceived by the brain, which guides both the timing and
outcome of behaviors in a context-dependent manner. Light is such a stimulus, which is …

Serotonin promotes exploitation in complex environments by accelerating decision-making

S Iwanir, AS Brown, S Nagy, D Najjar, A Kazakov… - BMC biology, 2016 - Springer
Background Fast responses can provide a competitive advantage when resources are
inhomogeneously distributed. The nematode Caenorhabditis elegans was shown to …