AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
H Doshi, K Spengler, A Godbole, YS Gee… - Microbiology …, 2023 - Am Soc Microbiol
Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing
mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon …
mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon …
[HTML][HTML] Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
S Chaturvedi, M Pablo, M Wolf, D Rosas-Rivera… - Cell, 2022 - cell.com
Across biological scales, gene-regulatory networks employ autorepression (negative
feedback) to maintain homeostasis and minimize failure from aberrant expression. Here, we …
feedback) to maintain homeostasis and minimize failure from aberrant expression. Here, we …
ICP22/IE63 mediated transcriptional regulation and immune evasion: two important survival strategies for alphaherpesviruses
Q He, Y Wu, M Wang, S Chen, R Jia, Q Yang… - Frontiers in …, 2021 - frontiersin.org
In the process of infecting the host, alphaherpesviruses have derived a series of adaptation
and survival strategies, such as latent infection, autophagy and immune evasion, to survive …
and survival strategies, such as latent infection, autophagy and immune evasion, to survive …
Deletion of Double Copies of the US1 Gene Reduces the Infectivity of Recombinant Duck Plague Virus In Vitro and In Vivo
Y Wu, S Tan, Q He, M Wang, S Chen, R Jia… - Microbiology …, 2022 - Am Soc Microbiol
Duck plague caused by duck plague virus (DPV) is one of the main diseases that seriously
endangers the production of waterfowl. DPV possesses a large genome consisting of 78 …
endangers the production of waterfowl. DPV possesses a large genome consisting of 78 …
Disrupting transcriptional feedback yields an escape-resistant antiviral
From bacteria to cancers, it has long been recognized that drug-resistant mutants emerge
quickly, causing significant morbidity and mortality–. Antiviral resistance in herpesviruses is …
quickly, causing significant morbidity and mortality–. Antiviral resistance in herpesviruses is …
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
B Zhang, J Ding, Z Ma - Viruses, 2023 - mdpi.com
The strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling
determines intracellular and extracellular physiological activities, including the successful …
determines intracellular and extracellular physiological activities, including the successful …
[PDF][PDF] Transcriptional Feedback Disruption Yields Escape-Resistant Antivirals
136 words Main Text: 1978 words Figures: 4 (color) Extended Data Figures: 9 not certified
by peer review) is the author/funder. All rights reserved. No reuse allowed without …
by peer review) is the author/funder. All rights reserved. No reuse allowed without …
[引用][C] Functional characterization of RNF213 as newly discovered ISG15 sensor during infection
L Martina - 2022 - biblio.ugent.be
SAMENVATTING INTRODUCTION-Chapter I: The Interferon pathway INTRODUCTION-
Chapter II: ISG15, an ubiquitin-like protein of the immune system INTRODUCTION-Chapter …
Chapter II: ISG15, an ubiquitin-like protein of the immune system INTRODUCTION-Chapter …