Germinal centers
GD Victora, MC Nussenzweig - Annual review of immunology, 2022 - annualreviews.org
Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …
[PDF][PDF] Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo
How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting
Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit,
engage and respond to T cell help (signal 2). Failure to receive signal 2 within a defined …
engage and respond to T cell help (signal 2). Failure to receive signal 2 within a defined …
New insights into B cells as antigen presenting cells
Highlights•The MHCII antigen presentation pathway has unique features in B cells.•The
MHCII antigen presentation pathway is regulated differently in different B cell subsets.•B cell …
MHCII antigen presentation pathway is regulated differently in different B cell subsets.•B cell …
[HTML][HTML] Positive selection in the light zone of germinal centers
R Nakagawa, DP Calado - Frontiers in Immunology, 2021 - frontiersin.org
Germinal centers (GCs) are essential sites for the production of high-affinity antibody
secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of …
secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of …
Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC),
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and …
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and …
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
N Hipp, H Symington, C Pastoret, G Caron… - Nature …, 2017 - nature.com
Plasma cell differentiation is a tightly regulated process that requires appropriate T cell helps
to reach the induction threshold. To further understand mechanisms by which T cell inputs …
to reach the induction threshold. To further understand mechanisms by which T cell inputs …
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity
while supporting high-affinity foreign antigen-specific humoral response. However, whether …
while supporting high-affinity foreign antigen-specific humoral response. However, whether …
[PDF][PDF] The amount of BCL6 in B cells shortly after antigen engagement determines their representation in subsequent germinal centers
It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B
cells influence the unfolding differentiation before germinal center (GC) formation. By …
cells influence the unfolding differentiation before germinal center (GC) formation. By …