The role of dendritic cells in autoimmunity

D Ganguly, S Haak, V Sisirak, B Reizis - Nature Reviews Immunology, 2013 - nature.com
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

Immune cell crosstalk in type 1 diabetes

A Lehuen, J Diana, P Zaccone, A Cooke - Nature Reviews Immunology, 2010 - nature.com
The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …

The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture

P Schnorrer, GMN Behrens… - Proceedings of the …, 2006 - National Acad Sciences
Mouse spleens contain three populations of conventional (CD11chigh) dendritic cells (DCs)
that play distinct functions. The CD8+ DC are unique in that they can present exogenous …

Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune …

JS Allen, K Pang, A Skowera, R Ellis, C Rackham… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—Immune-mediated destruction of β-cells resulting in type 1 diabetes involves
activation of proinflammatory, islet autoreactive T-cells, a process under the control of …

Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling

H Kared, H Adle-Biassette, E Foïs, A Masson, JF Bach… - Immunity, 2006 - cell.com
Cellular interactions promoting the in vivo expansion of CD4+ CD25+ Foxp3+ regulatory T
(Treg) cells for maintenance of immune tolerance remain poorly defined. Here we report that …

Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice

HY Won, JA Lee, ZS Park, JS Song, HY Kim, SM Jang… - PloS one, 2011 - journals.plos.org
Increasing evidence that decreased bone density and increased rates of bone fracture are
associated with abnormal metabolic states such as hyperglycemia and insulin resistance …

Intraocular oxygen distribution in advanced proliferative diabetic retinopathy

CAK Lange, P Stavrakas, UFO Luhmann… - American journal of …, 2011 - Elsevier
Purpose To determine the preretinal distribution of oxygen in advanced proliferative diabetic
retinopathy, and to investigate the relationship between intraocular oxygen tensions and …

The role of dendritic cell subsets and innate immunity in the pathogenesis of type 1 diabetes and other autoimmune diseases

JD Price, KV Tarbell - Frontiers in immunology, 2015 - frontiersin.org
Dendritic cells (DCs) are key antigen-presenting cells that have an important role in
autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of …

Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses

CM Lau, SA Nish, N Yogev, A Waisman… - Journal of Experimental …, 2016 - rupress.org
A common genetic alteration in acute myeloid leukemia is the internal tandem duplication
(ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD …

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat

D Zipris, E Lien, A Nair, JX Xie, DL Greiner… - The Journal of …, 2007 - journals.aai.org
Viral infections are associated epidemiologically with the expression of type 1 diabetes in
humans, but the mechanisms underlying this putative association are unknown. To …