The role of dendritic cells in autoimmunity
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …
Immune cell crosstalk in type 1 diabetes
The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …
The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
P Schnorrer, GMN Behrens… - Proceedings of the …, 2006 - National Acad Sciences
Mouse spleens contain three populations of conventional (CD11chigh) dendritic cells (DCs)
that play distinct functions. The CD8+ DC are unique in that they can present exogenous …
that play distinct functions. The CD8+ DC are unique in that they can present exogenous …
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune …
OBJECTIVE—Immune-mediated destruction of β-cells resulting in type 1 diabetes involves
activation of proinflammatory, islet autoreactive T-cells, a process under the control of …
activation of proinflammatory, islet autoreactive T-cells, a process under the control of …
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
H Kared, H Adle-Biassette, E Foïs, A Masson, JF Bach… - Immunity, 2006 - cell.com
Cellular interactions promoting the in vivo expansion of CD4+ CD25+ Foxp3+ regulatory T
(Treg) cells for maintenance of immune tolerance remain poorly defined. Here we report that …
(Treg) cells for maintenance of immune tolerance remain poorly defined. Here we report that …
Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice
HY Won, JA Lee, ZS Park, JS Song, HY Kim, SM Jang… - PloS one, 2011 - journals.plos.org
Increasing evidence that decreased bone density and increased rates of bone fracture are
associated with abnormal metabolic states such as hyperglycemia and insulin resistance …
associated with abnormal metabolic states such as hyperglycemia and insulin resistance …
Intraocular oxygen distribution in advanced proliferative diabetic retinopathy
Purpose To determine the preretinal distribution of oxygen in advanced proliferative diabetic
retinopathy, and to investigate the relationship between intraocular oxygen tensions and …
retinopathy, and to investigate the relationship between intraocular oxygen tensions and …
The role of dendritic cell subsets and innate immunity in the pathogenesis of type 1 diabetes and other autoimmune diseases
JD Price, KV Tarbell - Frontiers in immunology, 2015 - frontiersin.org
Dendritic cells (DCs) are key antigen-presenting cells that have an important role in
autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of …
autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of …
Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses
CM Lau, SA Nish, N Yogev, A Waisman… - Journal of Experimental …, 2016 - rupress.org
A common genetic alteration in acute myeloid leukemia is the internal tandem duplication
(ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD …
(ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD …
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
D Zipris, E Lien, A Nair, JX Xie, DL Greiner… - The Journal of …, 2007 - journals.aai.org
Viral infections are associated epidemiologically with the expression of type 1 diabetes in
humans, but the mechanisms underlying this putative association are unknown. To …
humans, but the mechanisms underlying this putative association are unknown. To …