Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …

Platelet activation and subsequent thrombus formation at sites of vascular injury is crucial for
normal hemostasis, but it can also cause myocardial infarction and stroke. The initial capture …

Summary The glycoprotein VI (GPVI)–FcR γ‐chain complex initiates powerful activation of
platelets by the subendothelial matrix proteins collagen and laminin through an …

This chapter summarizes current ideas about the intracellular signaling that drives platelet
responses to vascular injury. After a brief overview of platelet activation intended to place the …

Transcripts in platelets are largely produced in precursor megakaryocytes but remain
physiologically active as platelets translate RNAs and regulate protein/RNA levels. Recent …

Platelet adhesion and aggregation at the sites of vascular injury are key events for
thrombosis and haemostasis. It has been well demonstrated that interaction between …