Optical imaging represents one of the most essential tools in biological studies. Although
with great advances, bio-optical imaging still suffers from problems such as resolution …

Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Dynamic measurements of molecular machines can provide invaluable insights into their
mechanism, but these measurements have been challenging in living cells. Here, we …

This review describes the growing partnership between super-resolution imaging and
plasmonics, by describing the various ways in which the two topics mutually benefit one …

Many of the biological functions of a cell are dictated by the intricate motion of proteins within
its membrane over a spatial range of nanometres to tens of micrometres and time intervals of …

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular
cargos. Numerous kinesins and myosins have evolved to cope with the various transport …

Optical microscopes have for centuries been our window to the microscopic world. The
advent of single-molecule optics over the past few decades has ushered in a new era in …

Many cellular processes require large forces that are generated collectively by multiple
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …

In his 1665 treatise, Micrographia, Robert Hooke described the many observations he had
made using a microscope, including compartment-like structures in cork samples that he …

Intracellular transport is interspersed with frequent reversals in direction due to the presence
of opposing kinesin and dynein motors on organelles that are carried as cargo. The cause …