[HTML][HTML] Parkinson's disease and the environment
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an
estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic …
estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic …
Brain manganese and the balance between essential roles and neurotoxicity
RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
The role of manganese dysregulation in neurological disease: emerging evidence
D Budinger, S Barral, AKS Soo, MA Kurian - The Lancet Neurology, 2021 - thelancet.com
Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …
spectrum of neurological disorders reflects its importance in brain development and key …
The microbiota-gut-brain axis in health and disease and its implications for translational research
MA Schächtle, SP Rosshart - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Over the past decades, microbiome research has evolved rapidly and became a hot topic in
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …
[HTML][HTML] Redox toxicology of environmental chemicals causing oxidative stress
F Zheng, FM Gonçalves, Y Abiko, H Li, Y Kumagai… - Redox biology, 2020 - Elsevier
Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …
Copper, iron, and manganese toxicity in neuropsychiatric conditions
B Tarnacka, A Jopowicz, M Maślińska - International journal of molecular …, 2021 - mdpi.com
Copper, manganese, and iron are vital elements required for the appropriate development
and the general preservation of good health. Additionally, these essential metals play key …
and the general preservation of good health. Additionally, these essential metals play key …
The effects of manganese overexposure on brain health
Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal
to human health. Mn is present at low concentrations in a variety of dietary sources, which …
to human health. Mn is present at low concentrations in a variety of dietary sources, which …
Consequences of disturbing manganese homeostasis
J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …