[HTML][HTML] Parkinson's disease and the environment

N Ball, WP Teo, S Chandra, J Chapman - Frontiers in neurology, 2019 - frontiersin.org
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an
estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic …

Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

TV Peres, MRC Schettinger, P Chen… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

The role of manganese dysregulation in neurological disease: emerging evidence

D Budinger, S Barral, AKS Soo, MA Kurian - The Lancet Neurology, 2021 - thelancet.com
Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …

The microbiota-gut-brain axis in health and disease and its implications for translational research

MA Schächtle, SP Rosshart - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Over the past decades, microbiome research has evolved rapidly and became a hot topic in
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …

[HTML][HTML] Redox toxicology of environmental chemicals causing oxidative stress

F Zheng, FM Gonçalves, Y Abiko, H Li, Y Kumagai… - Redox biology, 2020 - Elsevier
Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

Copper, iron, and manganese toxicity in neuropsychiatric conditions

B Tarnacka, A Jopowicz, M Maślińska - International journal of molecular …, 2021 - mdpi.com
Copper, manganese, and iron are vital elements required for the appropriate development
and the general preservation of good health. Additionally, these essential metals play key …

The effects of manganese overexposure on brain health

MR Miah, OM Ijomone, COA Okoh, OK Ijomone… - Neurochemistry …, 2020 - Elsevier
Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal
to human health. Mn is present at low concentrations in a variety of dietary sources, which …

Consequences of disturbing manganese homeostasis

J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

S Sarkar, D Rokad, E Malovic, J Luo… - Science …, 2019 - science.org
Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …