The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - Molecular …, 2019 - nature.com
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

A hierarchical causal taxonomy of psychopathology across the life span.

BB Lahey, RF Krueger, PJ Rathouz… - Psychological …, 2017 - psycnet.apa.org
We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …

Diagnosis and management of bipolar disorders

FS Goes - bmj, 2023 - bmj.com
Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …

Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis

C Schiweck, G Arteaga-Henriquez, M Aichholzer… - Neuroscience & …, 2021 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common
mental disorders with a high degree of comorbidity. However, no systematic review with …

Genetics and genomics of psychiatric disease

DH Geschwind, J Flint - Science, 2015 - science.org
Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum

D Watson, HF Levin‐Aspenson, MA Waszczuk… - World …, 2022 - Wiley Online Library
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological
system that addresses shortcomings of traditional mental disorder diagnoses, including …

Culture and psychopathology: An attempt at reconsidering the role of social learning

P Fonagy, C Campbell, M Constantinou… - Development and …, 2022 - cambridge.org
This paper proposes a model for developmental psychopathology that is informed by recent
research suggestive of a single model of mental health disorder (the p factor) and seeks to …

Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta‐analyses

B Bortolato, CA Köhler, E Evangelou… - Bipolar …, 2017 - Wiley Online Library
Objectives The pathophysiology of bipolar disorder is likely to involve both genetic and
environmental risk factors. In our study, we aimed to perform a systematic search of …