Cannabis use and mental illness: understanding circuit dysfunction through preclinical models

BW Jenkins, JY Khokhar - Frontiers in psychiatry, 2021 - frontiersin.org
Patients with a serious mental illness often use cannabis at higher rates than the general
population and are also often diagnosed with cannabis use disorder. Clinical studies reveal …

Cannabinoid CB1 receptors regulate salivation

K Andreis, J Billingsley, K Naimi Shirazi… - Scientific reports, 2022 - nature.com
Saliva serves multiple important functions within the body that we typically take for granted,
such as helping prepare food for swallowing and defense against oral pathogens. Dry …

How depression and antidepressant drugs affect endocannabinoid system?—review of clinical and preclinical studies

J Dragon, E Obuchowicz - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
As major depressive disorder is becoming a more and more common issue in modern
society, it is crucial to discover new possible grip points for its diagnosis and antidepressive …

[HTML][HTML] Endocannabinoid system reactivity during stress processing in healthy humans

J Spohrs, M Prost, M Ulrich, PL Plener, L Bindila… - Biological …, 2022 - Elsevier
Stress underlies the development of various psychiatric disorders. Rodent studies suggest
an involvement of the endocannabinoid system in the modulation of the stress response …

[HTML][HTML] Clustering of cognitive phenotypes identifies susceptible and resilient offspring in a rat model of maternal immune activation and early-life stress

JM Lorusso, RM Woods, F McEwan, JD Glazier… - Brain, Behavior, & …, 2022 - Elsevier
Schizophrenia and other neurodevelopmental disorders often have very heterogeneous
symptoms, especially regarding cognition: while some individuals may exhibit deficient …

Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence

M Maulik, K Looschen, C Smith, K Johnson… - Pharmacology …, 2023 - Elsevier
Early life adversity in the form of poor postnatal care is a major developmental stressor
impacting behavior later in life. Previous studies have shown the impact of early life stress …

Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model

B Yuan, L Luo, C Hu, F Lin, T Yang, J Chen, T Li - Neuroscience Letters, 2023 - Elsevier
In addition to their core symptoms, most individuals with autism spectrum disorder (ASD)
also experience motor impairments. These impairments are often linked to the cerebellum …

Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats

A Demaili, A Portugalov, M Maroun, I Akirav… - Frontiers in Cellular …, 2024 - frontiersin.org
Several studies in both animal models and in humans have provided substantial evidence
that early life stress (ELS) induces long-term changes in behavior and brain function, making …

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

RA Miranda, VST Rodrigues, TC Peixoto… - … Origins of Health and …, 2023 - cambridge.org
Early nicotine exposure compromises offspring's phenotype at long-term in both sexes. We
hypothesize that offspring exposed to nicotine during breastfeeding show deregulated …

Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies

A Mundorf, SA Merklein, LC Rice… - Developmental …, 2024 - Wiley Online Library
Recent research has highlighted cerebellar involvement in cognition and several psychiatric
conditions such as mood and anxiety disorders and schizophrenia. Attention …