Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

Biomarkers for posttransplantation outcomes

S Paczesny - Blood, The Journal of the American Society of …, 2018 - ashpublications.org
During the last decade, the development of biomarkers for the complications seen after
allogeneic hematopoietic stem cell transplantation has expanded tremendously, with the …

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

J Du, K Paz, R Flynn, A Vulic… - Blood, The Journal …, 2017 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation is hampered by chronic graft-versus-host
disease (cGVHD), resulting in multiorgan fibrosis and diminished function. Fibrosis in lung …

[PDF][PDF] Validated graft-specific biomarkers identify patients at risk for chronic graft-versus-host disease and death

BR Logan, D Fu, A Howard, M Fei… - Journal of Clinical …, 2023 - Am Soc Clin Investig
BACKGROUND Chronic graft-versus-host disease (cGVHD) is a serious complication of
allogeneic hematopoietic cell transplantation (HCT). More accurate information regarding …

[HTML][HTML] An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition

E Forcade, K Paz, R Flynn, B Griesenauer, T Amet… - JCI insight, 2017 - ncbi.nlm.nih.gov
Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic stem
cell transplantation requiring novel therapies. CD146 and CCR5 are expressed by activated …

Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease

B Shrestha, K Walton, J Reff… - The Journal of …, 2020 - Am Soc Clin Investig
Graft-versus-host disease (GVHD) remains an important cause of morbidity and mortality
after allogeneic hematopoietic cell transplantation (allo-HCT). For decades, GVHD …

Biomarkers for allogeneic HCT outcomes

D Adom, C Rowan, T Adeniyan, J Yang… - Frontiers in …, 2020 - frontiersin.org
Allogeneic hematopoietic cell transplantation (HCT) remains the only curative therapy for
many hematological malignant and non-malignant disorders. However, key obstacles to the …

ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

D Adom, SR Dillon, J Yang, H Liu… - Science translational …, 2020 - science.org
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic
hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated …

Differential expression of miRNAs from extracellular vesicles in chronic graft-versus-host disease: A preliminary study.

P Łacina, RE Crossland, J Wielińska… - … in Clinical & …, 2023 - search.ebscohost.com
Background. Chronic graft-versus-host disease (cGvHD) is a complex disorder that typically
manifests after allogeneic hematopoietic stem cell transplantation (HSCT). It is a major …

Biomarkers for acute and chronic graft versus host disease: state of the art

L Giaccone, DG Faraci, S Butera, G Lia… - Expert Review of …, 2021 - Taylor & Francis
Introduction Despite significant advances in treatment and prevention, graft-versus-host
disease (GVHD) still represents the main cause of morbidity and mortality after allogeneic …