Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

The immune complement and the coagulation systems are blood-based proteolytic
cascades that are activated by pathway-specific triggers, based on protein–protein …

Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH …

Objectives The complement system is an important component of innate immunity. The
alternative pathway (AP) amplification loop is considered an essential feed forward …

The use of biomaterials in modern medicine has enabled advanced drug delivery strategies
and led to reduced morbidity and mortality in a variety of interventions such as …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …

Oxidative stress can impair the endothelial barrier and thereby enable autoantibody
migration in Neuromyelitis optica spectrum disorder (NMOSD). Tissue-specific vulnerability …

The complement system is an important defense mechanism against pathogens; however,
in certain pathologies, the system also attacks human cells, such as red blood cells (RBCs) …

The alternative pathway regulator Factor H-like protein 1 (FHL-1) is composed of the first 7 N-
terminal complement control protein domains of Factor H (FH) and protects host surfaces …

The complement system is an important part of the innate immune system, providing a
strong defense against pathogens and removing apoptotic cells and immune complexes …