[HTML][HTML] PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
R Liu, Y Chen, G Liu, C Li, Y Song, Z Cao, W Li… - Cell death & …, 2020 - nature.com
Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
Mitochondrial spare respiratory capacity: mechanisms, regulation, and significance in non‐transformed and cancer cells
P Marchetti, Q Fovez, N Germain, R Khamari… - The FASEB …, 2020 - Wiley Online Library
Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …
[HTML][HTML] The role of extracellular vesicles in the hallmarks of cancer and drug resistance
Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …
Organ-on-chip models of cancer metastasis for future personalized medicine: From chip to the patient
Most cancer patients do not die from the primary tumor but from its metastasis. Current in
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …
Fibroblasts in pancreatic cancer: molecular and clinical perspectives
Pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) are highly
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …
[HTML][HTML] Role of extracellular vesicles (EVs) in cell stress response and resistance to cancer therapy
CP O'Neill, KE Gilligan, RM Dwyer - Cancers, 2019 - mdpi.com
Extracellular vesicles (EVs) are nanosized particles released by all cells that have been
heralded as novel regulators of cell-to-cell communication. It is becoming increasingly clear …
heralded as novel regulators of cell-to-cell communication. It is becoming increasingly clear …
Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine
CPR Xavier, I Castro, HR Caires, D Ferreira… - Cancer Letters, 2021 - Elsevier
Tumour-associated macrophages have been implicated in pancreatic ductal
adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by …
adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by …
[HTML][HTML] Pioneer role of extracellular vesicles as modulators of cancer initiation in progression, drug therapy, and vaccine prospects
Cancer is one of the leading diseases, causing deaths worldwide. Nearly 10 million deaths
were reported in 2020 due to cancer alone. Several factors are involved in cancer …
were reported in 2020 due to cancer alone. Several factors are involved in cancer …