The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

Cell size is an important adaptive trait that influences nearly all aspects of cellular
physiology. Despite extensive characterization of the cell-cycle regulatory network, the …

Cells of a given type maintain a characteristic cell size to function efficiently in their
ecological or organismal context. They achieve this through the regulation of growth rates or …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

Highlights•G1 control networks are highly similar in budding yeast and mammals.•Lack of
protein sequence conservation suggests significant evolution of G1 control.•Accurate …

At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed
as a point in G1 that is passed when growth factor signaling initiates a positive feedback …

The molecular networks regulating the G1–S transition in budding yeast and mammals are
strikingly similar in network structure. However, many of the individual proteins performing …

In budding yeast cells, nutrient repletion induces rapid exit from quiescence and entry into a
round of growth and division. The G1 cyclin CLN3 is one of the earliest genes activated in …

The ability to specify and maintain discrete cell fates is essential for development. However,
the dynamics underlying selection and stability of distinct cell types remain poorly …