The roles of Gβγ and Gα in gating and regulation of GIRK channels
N Dascal, U Kahanovitch - International review of neurobiology, 2015 - Elsevier
Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
Localization and targeting of GIRK channels in mammalian central neurons
G protein-gated inwardly rectifying K+(GIRK/K ir 3) channels are critical to brain function.
They hyperpolarize neurons in response to activation of different G protein-coupled …
They hyperpolarize neurons in response to activation of different G protein-coupled …
Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling
SM Khan, A Min, S Gora, GM Houranieh, R Campden… - Cellular signalling, 2015 - Elsevier
Much is known about the how Gβγ subunits regulate effectors in response to G protein-
coupled receptor stimulation. However, there is still a lot we don't know about how specific …
coupled receptor stimulation. However, there is still a lot we don't know about how specific …
Design and construction of conformational biosensors to monitor ion channel activation: a prototype FlAsH/BRET-approach to Kir3 channels
Ion channels play a vital role in numerous physiological functions and drugs that target them
are actively pursued for development of novel therapeutic agents. Here we report a means …
are actively pursued for development of novel therapeutic agents. Here we report a means …
The Gβ1 and Gβ3 subunits differentially regulate rat vascular Kv7 channels
IA Greenwood, JB Stott - Frontiers in physiology, 2020 - frontiersin.org
Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a
variety of receptor mediated vasorelaxants. The Kv7. 4 isoform, abundant within the …
variety of receptor mediated vasorelaxants. The Kv7. 4 isoform, abundant within the …
[HTML][HTML] PPIP5K1 suppresses etoposide-triggered apoptosis
G Machkalyan, TE Hèbert, GJ Miller - Journal of Molecular …, 2016 - ncbi.nlm.nih.gov
Inositol hexakisphosphate kinase 2 (IP6K2) potentiates pro-apoptotic signalling and
increases the sensitivity of mammalian cells to cytotoxic agents. Diphosphoinositol …
increases the sensitivity of mammalian cells to cytotoxic agents. Diphosphoinositol …
The truth in complexes: perspectives on ion channel signaling nexuses in the nervous system
Ion channels are complex hetero-oligomeric structures characterized by large, dynamic
interaction networks, or “interactomes.” In addition to directing channel localization, density …
interaction networks, or “interactomes.” In addition to directing channel localization, density …
[图书][B] Gβγ dimers: Understanding their evolutionary divergence, specificity in signalling and non-canonical nuclear functions
SM Khan - 2016 - search.proquest.com
Heterotrimeric combinations of Gα, Gβ and Gγ subunits interact with G protein-coupled
receptors (GPCRs) as signal transducers. The presence of G proteins with specific subunit …
receptors (GPCRs) as signal transducers. The presence of G proteins with specific subunit …