Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders

S Dash, YA Syed, MR Khan - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

Effects of aerobic exercise on metabolic syndrome, cardiorespiratory fitness, and symptoms in schizophrenia include decreased mortality

A Schmitt, I Maurus, MJ Rossner, A Röh… - Frontiers in …, 2018 - frontiersin.org
Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%.
People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the …

Metagenome-wide association of gut microbiome features for schizophrenia

F Zhu, Y Ju, W Wang, Q Wang, R Guo, Q Ma… - Nature …, 2020 - nature.com
Evidence is mounting that the gut-brain axis plays an important role in mental diseases
fueling mechanistic investigations to provide a basis for future targeted interventions …

Cardiometabolic risk factors associated with brain age and accelerated brain ageing

D Beck, AMG de Lange, ML Pedersen… - Human brain …, 2022 - Wiley Online Library
The structure and integrity of the ageing brain is interchangeably linked to physical health,
and cardiometabolic risk factors (CMRs) are associated with dementia and other brain …

Obesity in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates and relationship with cognitive deficits

Y Tian, D Liu, D Wang, J Wang, H Xu, Q Dai… - Schizophrenia …, 2020 - Elsevier
The prevalence of obesity in schizophrenia patients is high, especially in chronic and
medicated patients. Few studies have explored the relationships between obesity, cognition …

Evidence of association between obesity and lower cerebral myelin content in cognitively unimpaired adults

M Bouhrara, N Khattar, P Elango, SM Resnick… - International Journal of …, 2021 - nature.com
Background Myelin loss is a central feature of several neurodegenerative diseases,
including Alzheimer's disease (AD). In animal studies, a link has been established between …

Longitudinal course of cognition in schizophrenia: Does treatment resistance play a role?

M Spangaro, F Martini, M Bechi, M Buonocore… - Journal of Psychiatric …, 2021 - Elsevier
Abstract Treatment-resistant schizophrenia (TRS) represents a main clinical issue,
associated with worse functional outcome and higher healthcare costs. Clozapine is the …

Characterizing serum amino acids in schizophrenic patients: Correlations with gut microbes

Q Ma, F Gao, L Zhou, Y Fan, B Zhao, W Xi… - Journal of Psychiatric …, 2022 - Elsevier
Amino acid abnormalities have been suggested to be a key pathophysiological mechanism
in schizophrenia (SZ). Recently, gut microbes were found to be critically involved in mental …

Bilateral anterior corona radiata microstructure organisation relates to impaired social cognition in schizophrenia

T Burke, L Holleran, D Mothersill, J Lyons… - Schizophrenia …, 2023 - Elsevier
Abstract Objective The Corona Radiata (CR) is a large white matter tract in the brain
comprising of the anterior CR (aCR), superior CR (sCR), and posterior CR (pCR), which …

The impact of inflammation on neurocognition and risk for psychosis: a critical review

S Kogan, LH Ospina, VA Mittal, D Kimhy - European archives of psychiatry …, 2020 - Springer
Neurocognitive difficulties are highly prevalent among people with schizophrenia and have
been linked to increased inflammation, as well as dysfunction and disability. Poor …