The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

The Kelch‐like ECH‐associated protein 1/nuclear factor erythroid‐derived 2‐like 2 (KEAP 1‐
NRF 2) system is a pivotal defense mechanism against oxidative and electrophilic stress …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …

Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is
a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2 …

Simple Summary Reprogramming metabolism is a hallmark of cancer. Warburg's effect,
defined as increased aerobic glycolysis at the expense of mitochondrial respiration in …

Accumulating evidence suggests that constitutively active Nrf2 has a pivotal role in cancer
as it induces pro-survival genes that promote cancer cell proliferation and chemoresistance …

Nuclear factor erythroid 2-like factor 2 (NRF2) is a master regulator of the antioxidant
enzymes and the detoxification proteins that play major roles in redox homeostasis …

Background Chrysin, an active natural bioflavonoid, has been proven to protect against
carcinogenesis. However, the role of chrysin in glioblastoma and the potential molecular …

Glioblastoma multiforme (GBM) is one of the most aggressive glial cell tumors in adults.
Although current treatment options for GBM offer some therapeutic benefit, median survival …