Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review

MS Salahudeen, SB Duffull, PS Nishtala - BMC geriatrics, 2015 - Springer
Background The cumulative effect of taking multiple medicines with anticholinergic
properties termed as anticholinergic burden can adversely impact cognition, physical …

Anticholinergic drug burden tools/scales and adverse outcomes in different clinical settings: a systematic review of reviews

TJ Welsh, V van der Wardt, G Ojo, AL Gordon… - Drugs & aging, 2018 - Springer
Background Cumulative anticholinergic exposure (anticholinergic burden) has been linked
to a number of adverse outcomes. To conduct research in this area, an agreed approach to …

Polypharmacy among adults aged 65 years and older in the United States: 1988–2010

CJ Charlesworth, E Smit, DSH Lee… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. Older adults frequently have several chronic health conditions which require
multiple medications. We illustrated trends in prescription medication use over 20 years in …

Prevalence of potentially inappropriate medication use in older adults using the 2012 Beers criteria

AJ Davidoff, GE Miller, EM Sarpong… - Journal of the …, 2015 - Wiley Online Library
Objectives To use the most recently available population‐based data to estimate potentially
inappropriate medication (PIM) prevalence under the 2012 update of the Beers list of PIM s …

Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people

MS Salahudeen, SN Hilmer… - Journal of the American …, 2015 - Wiley Online Library
Objectives To investigate whether anticholinergic burden scores from nine published
anticholinergic scales are associated with adverse health outcomes, including hospital …

Drug Burden Index in older adults: theoretical and practical issues

L Kouladjian, D Gnjidic, TF Chen… - … interventions in aging, 2014 - Taylor & Francis
Anticholinergic and sedative medications are commonly used in older adults and are
associated with adverse clinical outcomes. The Drug Burden Index was developed to …

DEFEAT-polypharmacy: deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities

N Ailabouni, D Mangin, PS Nishtala - International journal of clinical …, 2019 - Springer
Background Prolonged use of anticholinergic and sedative medicines is correlated with
worsening cognition and physical function decline. Deprescribing is a proposed intervention …

Quantifying anticholinergic burden and sedative load in older adults with polypharmacy: a systematic review of risk scales and models

SB Al Rihani, M Deodhar, LI Darakjian, P Dow… - Drugs & aging, 2021 - Springer
Background Patients taking medication with high anticholinergic and sedative properties are
at increased risk of experiencing poor cognitive and physical outcomes. Therefore, precise …

Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review

A Lisibach, V Benelli, MG Ceppi… - European journal of …, 2021 - Springer
Purpose Older people are at risk of anticholinergic side effects due to changes affecting drug
elimination and higher sensitivity to drug's side effects. Anticholinergic burden scales (ABS) …

The association between anticholinergic medication burden and health related outcomes in the 'oldest old': a systematic review of the literature

K Cardwell, CM Hughes, C Ryan - Drugs & aging, 2015 - Springer
Background Increased exposure to anticholinergic medication is problematic, particularly in
those aged 80 years and older. Objective The aim of this systematic review was to identify …