Sex differences in the vascular function and related mechanisms: role of 17β-estradiol
MR Pabbidi, M Kuppusamy… - American Journal …, 2018 - journals.physiology.org
The incidence of cardiovascular disease (CVD) is lower in premenopausal women but
increases with age and menopause compared with similarly aged men. Based on the …
increases with age and menopause compared with similarly aged men. Based on the …
Cytochrome P450-derived eicosanoids and heart function
KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …
enzymes, which are important in the metabolism of foreign and endogenous compounds …
Sex differences in eicosanoid formation and metabolism: a possible mediator of sex discrepancies in cardiovascular diseases
SH Gerges, AOS El-Kadi - Pharmacology & therapeutics, 2022 - Elsevier
Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …
Sex-biased eicosanoid biology: impact for sex differences in inflammation and consequences for pharmacotherapy
The incidence, severity and progression of autoimmune diseases (eg scleroderma, multiple
sclerosis, rheumatoid arthritis) and certain inflammatory diseases (eg asthma) are sex …
sclerosis, rheumatoid arthritis) and certain inflammatory diseases (eg asthma) are sex …
Sex differences in the cerebral collateral circulation
JE Faber, SM Moore, JL Lucitti, A Aghajanian… - Translational stroke …, 2017 - Springer
Premenopausal women and intact female rodents sustain smaller cerebral infarctions than
males. Several sex-dependent differences have been identified as potential contributors, but …
males. Several sex-dependent differences have been identified as potential contributors, but …
Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation
To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …
[HTML][HTML] Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
[HTML][HTML] Sexually dimorphic regulation of EET synthesis and metabolism: roles of estrogen
A Huang, D Sun - Frontiers in pharmacology, 2018 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …
Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ
The relationship between soluble epoxide hydrolase (sEH) and coronary reactive
hyperemia (CRH) response to a brief ischemic insult is not known. Epoxyeicosatrienoic …
hyperemia (CRH) response to a brief ischemic insult is not known. Epoxyeicosatrienoic …
Sexually dimorphic adaptation of cardiac function: roles of epoxyeicosatrienoic acid and peroxisome proliferator‐activated receptors
Epoxyeicosatrienoic acids (EET s) are cardioprotective mediators metabolized by soluble
epoxide hydrolase (sEH) to form corresponding diols (DHET s). As a sex‐susceptible target …
epoxide hydrolase (sEH) to form corresponding diols (DHET s). As a sex‐susceptible target …