This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

Increased arterial stiffness and vascular remodeling precede and are consequences of
hypertension. They also contribute to the development and progression of life-threatening …

Key points Candesartan, an inverse agonist of the type 1 angiotensin II receptor (AT1R),
causes a concentration‐dependent inhibition of pressure‐dependent myogenic tone …

Objective Aortic vascular stiffness has been implicated in the development of cardiovascular
disease (CVD) and chronic kidney disease (CKD) in obese individuals. However, the …

Consumption of diets high in fat, sugar, and salt (Western diet, WD) is associated with
accelerated arterial stiffening, a major independent risk factor for cardiovascular disease …

BACKGROUND: Plasma concentration of PAI-1 (plasminogen activator inhibitor-1)
correlates with arterial stiffness. Vascular smooth muscle cells (SMCs) express PAI-1, and …

BACKGROUND Although numerous recent studies have shown a strong link between
inflammation and hypertension, the underlying mechanisms by which inflammatory …

Increased sitting time, the most common form of sedentary behavior, is an independent risk
factor for all-cause and cardiovascular disease mortality; however, the mechanisms linking …