Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role
in the physiology of the synovium by producing certain components of the synovial fluid and …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Rheumatoid arthritis (RA) is a systemic autoimmune disease underlying a cascade of
chronic inflammatory processes. Over the past decades, the response rate of effective RA …

Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that
remains an unmet medical need despite improved therapy. This limitation likely reflects the …

Abstract Fibroblast-like synoviocytes (FLSs), play a key role in perpetuating synovial
inflammation and bone erosion in rheumatoid arthritis (RA), however, the underlying …

Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like
synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the …

Abstract Eotaxin-1 (CCL11) induces the migration of different leukocyte types by interacting
with CCR3. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are pathogenic …

Rheumatoid arthritis (RA) is a chronic immune-mediated disorder, mainly characterized by
synovial inflammation and joint damage. If insufficiently treated, RA can lead to irreversible …

Background Fibroblast-like synoviocytes (FLSs) play a critical role in promoting synovial
aggression and joint destruction in rheumatoid arthritis (RA). Cyclic GMP‐AMP synthase …