The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Targeting the loss of cGAS/STING signaling in cancer
N Sasaki, M Homme, S Kitajima - Cancer Science, 2023 - Wiley Online Library
The cGAS/STING pathway provides a key host defense mechanism by detecting the
accumulation of cytoplasmic double‐stranded DNA (dsDNA) and mediating innate and …
accumulation of cytoplasmic double‐stranded DNA (dsDNA) and mediating innate and …
Longitudinal on-treatment circulating tumor DNA as a biomarker for real-time dynamic risk monitoring in cancer patients: the EP-SEASON study
J Lv, LX Xu, ZX Li, L Lin, CF Wu, TQ Quan, ZC Zhen… - Cancer cell, 2024 - cell.com
Recurrence risks of cancer patient can change during treatment as a result of treatment-
related tumor evolution. However, biomarkers that can monitor these changes are lacking …
related tumor evolution. However, biomarkers that can monitor these changes are lacking …
A blueprint for tumor-infiltrating B cells across human cancers
J Ma, Y Wu, L Ma, X Yang, T Zhang, G Song, T Li… - Science, 2024 - science.org
B lymphocytes are essential mediators of humoral immunity and play multiple roles in
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …
[HTML][HTML] Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
J Zhang, S Yu, Q Peng, P Wang… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
Ultrasound-Induced Gold Nanoparticle United with Acoustic Reprogramming of Macrophages for Enhanced Cancer Therapy
Q Tang, F Zhang, L Luo, Y Duan, T Zhu… - … Applied Materials & …, 2023 - ACS Publications
Sonodynamic therapy (SDT) has considerable potential in cancer treatment and exhibits
high tissue penetration with minimal damage to healthy tissues. The efficiency of SDT is …
high tissue penetration with minimal damage to healthy tissues. The efficiency of SDT is …
Pancreatic ductal adenocarcinoma cells reshape the immune microenvironment: Molecular mechanisms and therapeutic targets
Y Zhao, C Qin, C Lin, Z Li, B Zhao, T Li, X Zhang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a digestive system malignancy characterized
by challenging early detection, limited treatment alternatives, and generally poor prognosis …
by challenging early detection, limited treatment alternatives, and generally poor prognosis …
Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention
Z Zhang, M Chen, W Zhan, Y Chen, T Wang… - Cell Death …, 2023 - nature.com
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …
Unraveling the association between gut microbiota and chemotherapy efficacy: a two-sample Mendelian randomization study
Z Jia, X Liu, W Liao - Microbiology spectrum, 2024 - journals.asm.org
Emerging evidence has underscored the complex link between gut microbiota and
chemotherapy efficacy; however, establishing causality remains elusive due to confounding …
chemotherapy efficacy; however, establishing causality remains elusive due to confounding …
Analysis of the clinical efficacy and safety of anti‐PD‐1 immune checkpoint inhibitors in locally advanced nasopharyngeal cancer
S Shi, B Li, P Zhou, L Chen, H Li, Y Wang… - Cancer …, 2024 - Wiley Online Library
Objective To analyze the efficacy and adverse effects of anti‐PD‐1 immune checkpoint
inhibitors aimed at nasopharyngeal carcinoma (NPC). Methods During the first stage of the …
inhibitors aimed at nasopharyngeal carcinoma (NPC). Methods During the first stage of the …