Analysis of Diagnostic Biomarkers for Malaria: Prospects on Rapid diagnostic test development

A Yadav, K Verma, K Singh, S Tyagi, L Kori… - Microbial …, 2024 - Elsevier
Accurate malaria diagnosis remains a formidable challenge in remote regions of malaria-
endemic areas globally. Existing diagnostic methods predominantly rely on microscopy and …

Novel Babesia bovis exported proteins that modify properties of infected red blood cells

H Hakimi, TJ Templeton, M Sakaguchi… - PLoS …, 2020 - journals.plos.org
Babesia bovis causes a pathogenic form of babesiosis in cattle. Following invasion of red
blood cells (RBCs) the parasite extensively modifies host cell structural and mechanical …

Genome Editing of Babesia bovis Using the CRISPR/Cas9 System

H Hakimi, T Ishizaki, Y Kegawa, O Kaneko, S Kawazu… - MSphere, 2019 - Am Soc Microbiol
Babesia bovis, the most virulent causative agent of bovine babesiosis, is prevalent in
tropical and subtropical regions of the world. Although the whole-genome sequence was …

Establishment of transient and stable transfection systems for Babesia ovata

H Hakimi, J Yamagishi, Y Kegawa, O Kaneko… - Parasites & vectors, 2016 - Springer
Background Bovine babesiosis is a tick-borne disease caused by several species of
Babesia which produce acute and fatal disease in cattle and affect livestock industry …

Molecular cloning, expression and oxidative stress response of a mitochondrial thioredoxin peroxidase gene (AccTpx-3) from Apis cerana cerana

P Yao, W Lu, F Meng, X Wang, B Xu, X Guo - Journal of insect physiology, 2013 - Elsevier
Thioredoxin peroxidase (Tpxs) plays an important role in maintaining redox homeostasis
and in protecting organisms from the accumulation of toxic reactive oxygen species (ROS) …

The redox systems of Plasmodium falciparum and Plasmodium vivax: comparison, in silico analyses and inhibitor studies

F Mohring, J Pretzel, E Jortzik… - Current Medicinal …, 2014 - ingentaconnect.com
Plasmodium falciparum is responsible for the most severe form of human malaria. P. vivax,
in contrast, is the most widespread malaria parasite with an enormous impact on health and …

A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti

H Zhang, Z Wang, J Huang, J Cao, Y Zhou… - Frontiers in Veterinary …, 2020 - frontiersin.org
Thioredoxin peroxidases (TPxs) are ubiquitous cysteine-based peroxidases that reduce
peroxides as part of antioxidant defenses and redox signaling and are essential for Babesia …

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

K Haeussler, I Berneburg, E Jortzik, J Hahn, M Rahbari… - Malaria journal, 2019 - Springer
Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and
RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate …

Isolation of viable Babesia bovis merozoites to study parasite invasion

H Hakimi, M Asada, T Ishizaki, S Kawazu - Scientific reports, 2021 - nature.com
Babesia parasite invades exclusively red blood cell (RBC) in mammalian host and induces
alterations to host cell for survival. Despite the importance of Babesia in livestock industry …

First Report of a Peroxiredoxin Homologue in Jellyfish: Molecular Cloning, Expression and Functional Characterization of CcPrx4 from Cyanea capillata

Z Ruan, G Liu, B Wang, Y Zhou, J Lu, Q Wang, J Zhao… - Marine drugs, 2014 - mdpi.com
We first identified and characterized a novel peroxiredoxin (Prx), designated as CcPrx4, from
the cDNA library of the tentacle of the jellyfish Cyanea capillata. The full-length cDNA …