Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

Diabetic nephropathy (DN) is known as a major microvascular complication in type 1
diabetes. The effect of insulin treatment alone on controlling blood glucose is unsatisfactory …

Ferroptosis, an autophagy‐dependent cell death, is characterized by lipid peroxidation and
iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus …

In our previous study, we reported that sirtuin5 (SIRT5), a member of the NAD+-dependent
class III histone deacetylase family, is highly expressed in colorectal cancer (CRC). Herein …

Background: High salt intake is the leading dietary risk factor for cardiovascular diseases.
Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty …

Background Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is
a hallmark of Parkinson's disease (PD) and related synucleinopathies. Although …

A ketogenic diet (KD; high-fat, low-carbohydrate) can benefit refractory epilepsy, but
underlying mechanisms are unknown. We used mice inducibly expressing a mutated form of …

Cigarette smoke (CS)-induced oxidative stress drives the pathogenesis of respiratory
diseases, in which the activation and accumulation of reactive oxygen species (ROS) play …

Lipophagy is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral
lipases. Chaperon-mediated autophagy (CMA) triggers lipid droplets (LDs) breakdown, to …