[HTML][HTML] From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
M Chemudupati, AD Kenney, S Bonifati, A Zani… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …
viruses. These proteins are critical components of the innate immune system and function to …
SAMHD1 functions and human diseases
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways
S Chen, S Bonifati, Z Qin, C St. Gelais… - Proceedings of the …, 2018 - National Acad Sciences
Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …
A G1‐like state allows HIV‐1 to bypass SAMHD 1 restriction in macrophages
P Mlcochova, KA Sutherland, SA Watters… - The EMBO …, 2017 - embopress.org
An unresolved question is how HIV‐1 achieves efficient replication in terminally
differentiated macrophages despite the restriction factor SAMHD 1. We reveal inducible …
differentiated macrophages despite the restriction factor SAMHD 1. We reveal inducible …
Brain microglial cells are highly susceptible to HIV-1 infection and spread
JJ Cenker, RD Stultz, D McDonald - AIDS research and human …, 2017 - liebertpub.com
Macrophages are a target of human immunodeficiency virus type 1 (HIV-1) infection and
may serve as an important reservoir of the virus in the body, particularly after depletion of …
may serve as an important reservoir of the virus in the body, particularly after depletion of …
Conserved herpesvirus protein kinases target SAMHD1 to facilitate virus replication
To ensure a successful infection, herpesviruses have developed elegant strategies to
counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 …
counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 …
SAMHD1 and the innate immune response to cytosolic DNA during DNA replication
Highlights•The cGAS-STING pathway signals cytosolic DNA resulting from endogenous
DNA damage.•This pathway has both pro-tumoral and anti-tumoral roles depending on the …
DNA damage.•This pathway has both pro-tumoral and anti-tumoral roles depending on the …
Ribonucleotide reductase inhibitors suppress SAMHD 1 ara‐CTP ase activity enhancing cytarabine efficacy
The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute
myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but …
myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but …
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
Recently, we demonstrated that sterile α motif and HD domain containing protein 1
(SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity …
(SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity …
SAMHD1 in cancer: curse or cure?
K Schott, C Majer, A Bulashevska, L Childs… - Journal of Molecular …, 2022 - Springer
Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described
as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) …
as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) …