Frailty and depression are important issues affecting older adults. Depressive syndrome
may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews …

Incidence rates of cognitive impairment and dementia are rising with the ageing population.
Meanwhile, the limited success of current treatments has led to a search for early markers of …

The Medical Journal of Australia Page 1 MJA • Volume 184 Number 2 • 16 January 2006 81
VIEWPOINT The Medical Journal of Australia ISSN: 0025729X 16 January 2006 184 2 81-83 …

Whereas physical impairment is the main hallmark of frailty, evidence suggests that other
dimensions, such as psychological, cognitive and social factors also contribute to this …

Declines in both physical and cognitive function are associated with increasing age.
Understanding the physiological link between physical frailty and cognitive decline may …

Background. The primary biologic mechanism that causes frailty in older persons has never
been adequately explained. According to recent views, oxidative stress may be the driving …

Context: As men age, the prevalence of frailty increases whereas levels of androgens
decline. Little is known about the relation between these factors. Objective: The aim of this …

Objectives To determine the effects of baseline and changes in frailty states on subsequent
depressive symptoms, and whether sleep duration would modify these effects. Design …

In older age, frailty is a detrimental transitional status of the aging process featuring an
increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves …

Objective To examine the association between cognitive frailty and long-term all-cause
mortality and the stratified and combined associations of physical activity and cognitive frailty …